1. 2008년 6월 국내 연구논문 발표 실적
  2006년 6월 한달 동안 PubMed에 등록된 국내 생물정보학 관련 발표 논문(제1 저자를 기준으로 한국에서 발표한 논문을 대상으로 12가지의 생물정보학 관련 keyword로 검색하여 정리한 결과)

2. 국외 뉴스
2008년 6월 주요 국외 뉴스 클리핑

날짜	내용
6.28	Complexity of Crohn's disease revealed as 'gene' count tops 30 New research has trebled the number of genetic regions known to be implicated in Crohn's disease, a form of inflammatory bowel disease, to over thirty. The research, published today in the journal Nature Genetics, has identified a number of potential new ...
6.27	Mechanism and function of humor identified by new evolutionary theory The pattern recognition theory of humor is an evolutionary and cognitive explanation of how and why any individual finds anything funny. Effectively it explains that humor occurs when the brain recognizes a pattern that surprises it. It also identifies im ...
6.22	DNA study unlocks mystery to diverse traits in dogs In the cover story of tomorrow's edition of the science journal Genetics, research reveals locations in a dog's DNA that contain genes that scientists believe contribute to differences in body and skull shape, weight, fur color and length -- and possibl ...
6.19	Gene-expression profiling of the effects of liver toxins Gene-expression data from liver tissue or whole blood can be used to classify histopathologic differences in the effects of hepatotoxins. It is hoped that these findings, published in BioMed Central's open access journal Genome Biology will lead to a mor ...
6.16	Computer predicts anti-cancer molecules A new computer-based method of analyzing cellular activity has correctly predicted the anti-tumor activity of several molecules. Research published today in BioMed Central's open access journal Molecular Cancer describes 'CoMet' -- a tool that studies ...
6.12	Centromeres cross over, a lot Recombination at centromeres is higher than anywhere else on the chromosome, even though methyltransferases do their best to prevent it, say Jaco et al., as published in the June 16 issue of the Journal of Cell Biology. ...
6.11	Researchers reveal insights into hidden world of protein folding Proteins, long and linear when first made, must fold into specific configurations before they can properly do their job in a cell. How they are folded is a mystery, but Stanford researcher Judith Frydman has begun prying the lid off a type of molecule cal ...

3. 국내외 전문연구동향 (국내뉴스 포함)

날짜	내용
6.27	생물정보학 이용, 천식 유발 후보유전자 발견
6.25	활유어 (amphioxus)의 게놈 해독에 성공
6.23	생명의 기원 논쟁, 다시 불붙나?
6.23	DNA로 姓을 찾는다
6.23	'머리카락' 검사로 유방암 정확히 찾아내는 검사법 개발
6.23	유전자 진단 기술, 더욱 진보한다...포항공과대학교 화학과 김병현 교수
6.20	게놈 연구, 일본 제약 시장에 IT의 물결 - 국내외 기업의 새로운 경쟁
6.18	생식세포의 탄생기구에 관련한 유전자군의 해명
6.16	'내 손 안에 병원' 스마트 바이오칩
6.13	암을 포함한 심장질환, 뇌질환 등 35가지 질환의 SNP 정보를 공개
6.9	"환자 바이오마커 따라 암 표적공격 맞춤치료"

4. PubMed에 소개된 생물정보학관련 5월 주요리뷰(편집자 주)

5. PLoS Computational Biology Journals(편집자 주: Editor's Pick)

제목	요약
Regulation of Signal Duration and the Statistical Dynamics of Kinase Activation by Scaffold Proteins	The authors use a computational approach to simulate the behavior of a model signal transduction module (a kinase cascade) in the presence of scaffolding proteins, revealing mechanisms for how scaffolds can dynamically regulate the timing of cell signaling. PLos Computational Biology 2008 June 4;(6) : e10000099
Machine-Learning Approaches for Classifying Haplogroup from Y Chromosome STR Data	Schlecht et al. use modern machine-learning algorithms to assign a sampled Y chromosome to a haplogroup by scoring a relatively small number of Y-linked short tandem repeats (STRs). This novel alternative to SNP analysis provides deep ancestry information in a cost-effective and accurate manner. PLos Computational Biology 2008 June 4;(6) : e10000093

6. Bioinformatics 저널 주요논문(편집자 주, IF, 인용지수=4.894)

Number	Title
Bioinformatics Volume 24, Number 11	Simple is beautiful: a straightforward approach to improve the delineation of true and false positives in PSI-BLAST searches 2008 24(11) :1339-1343
	Annotation-Modules: a tool for finding significant combinations of multisource annotations for gene lists 2008 24(11) :1386-1393
Bioinformatics Volume 24, Number 12	Cytoscape ESP: simple search of complex biological networks 2008 24(12) :1465-1466
	jSquid: a Java applet for graphical on-line network exploration 2008 24(12) :1467-1468

7. BMC Journals
  7-1. BMC Bioinformatics (IF, 인용지수 = 3.62)

제 목	요 약
Better resolution of chromosome rearrangements	By comparing an organism's chromosomes to those of closely related species using a segmentation algorithm, breakpoints can be precisely delimited and their internal structure described, providing insights into the mechanisms and evolutionary properties of chromosomal rearrangements. BMC Bioinformatics 2008, 9 : 286
Visualization of genetic variations	Using the new software toolkit VariVis, curators of online locus-specific databases can now generate graphical models of gene sequences and their mutations to encourage greater understanding of the data and facilitate access. BMC Bioinformatics 2008, 9 : 206
Mind the GAPscreener	PubMed abstracts can now be effectively screened for articles related to human genetic association studies and genome epidemiology using GAPscreener, a free java-based tool. BMC Bioinformatics 2008, 9 : 205

참고: BMC Bioinformatics: Most viewed articles in past 30 days
  7-2. BMC Genomics Research highlights (Impact Factor=4.03)

제 목	요 약
Baseline variation in toxicogenomic data	An inter-laboratory meta-analysis of more that 500 microarrays from the liver and kidney of control rats defined key sources of variability in control animals and will aid in the efficient design of future toxicogenomics experiments. BMC Genomics 2008, 9 : 285
Earthworm genetics takes on soil toxins	Earthworms exposed to cadmium, the herbicide atrazine or the polyaromatic hydrocarbon fluoroanthene can be distinguished from worms not exposed to pollutants by their characteristic genetic profiles, a novel means of monitoring contaminated soil ecosystems BMC Genomics 2008, 9 : 266
Hidden layers of human small RNAs	Unbiased sequencing of 19 to 40 nucleotide-long RNAs in human cells suggests the existence of small RNAs originating from longer, more well-characterized non-coding RNAs, such as tRNAs, and also reveals six previously unknown miRNAs. BMC Genomics 2008, 9 : 157

참고: BMC Genomics: Most viewed articles in past 30 days

[Recruit]

1. ISMB 2008
1) Keynote Speakers
2) ISMB 2008 Accepted Papers
3) Program
4) Highlights Track

2. 2008 Bioinformatics Research Papers by EurekAlert

-. Phylogeny-Aware Gap Placement Prevents Errors in Sequence Alignment and Evolutionary Analysis
By Ari Loytynoja and Nick Goldman.
Science, 20 June 2008: Vol. 320. no. 5883, pp. 1632 - 1635 DOI: 10.1126/science.1158395.

-. Discovering Sequence Motifs with Arbitrary Insertions and Deletions
By Martin C. Frith, et al.
PLoS Computational Biology, 4(5): e1000071. doi:10.1371/journal.pcbi.1000071 (2008).

-. Genome sequencing and analysis of the biomass-degrading fungus Trichoderma reesei.
By Diego Martinez, et al.
Nature Biotechnology 26, 553 - 560 Published online: 4 May 2008 | doi:10.1038/nbt1403 (2008).

-. Exon level integration of proteomics and microarray data
By Danny Bitton, et al.
BMC Bioinformatics 2008, 9:118doi:10.1186/1471-2105-9-118 (2008).

-. Geographic Patterns of Genome Admixture in Latin American Mestizos
By Sijia Wang, et al.
PLoS Genet 4(3): e1000037. doi:10.1371/journal.pgen.1000037 (2008).

-. Global Analysis of Genetic, Epigenetic and Transcriptional Polymorphisms in Arabidopsis thaliana Using Whole Genome Tiling Arrays
By Xu Zhang, et al.
PLoS Genet 4(3): e1000032. doi:10.1371/journal.pgen.1000032 (2008).

-. Worldwide Human Relationships Inferred from Genome-Wide Patterns of Variation
By Jun Z. Li, et al.
Science, Vol. 319. no. 5866, pp. 1100-1104, DOI: 10.1126/science.1153717) (2008).

-. Evolution of Complex Modular Biological Networks
By Arend Hintze and Christoph Adami.
PLoS Comput Biol 4(2): e23 doi:10.1371/journal.pcbi.0040023 (2008).

-. Genome resequencing and genetic variation
By Abraham L. Brass et al.
Science, 10.1126/science.1152725 (2008).

-. Identification of Host Proteins Required for HIV Infection Through a Functional Genomic Screen
By Arend Hintze and Christoph Adami.
PLoS Comput Biol 4(2): e23 doi:10.1371/journal.pcbi.0040023 (2008).

자료 : http://www.eurekalert.org/context.php?context=bio&show=research

3. Genome Browser
UCSC genome browser tutorial

4. New Technology
Next-Generation DNA Sequencing Methods